ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 30 Issue : 1 Year : 2023
Antioxidants Prolong Survival of Lymphocytes [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2000; 13(4): 141-145

Antioxidants Prolong Survival of Lymphocytes

Fakher S. Al-Ani1, Israa F. Al-Samaraee1, Anam R. Abdul-Razzak2
1Department of Physiology, Saddam College of Medicine, Saddam University, Iraq.
2Department of Anatomy, Saddam College of Medicine, Saddam University, Iraq.

The trace metals (antioxidants) were studied to elucidate their effects to prolong lymphocyte survival by preventing programmed cell death (apoptosis), these trace metals; ZnCl2 (4.77x10-5 M), CuSO4 (15x10-6 M) were added to the lymphocyte cultures on the third day in RPMI media. H2O2 was used to promote apoptosis.
Apoptosis was assessed morphologically (by phase contrast microscopy and DNA quantitation) and biochemically (MDA production, thiol, and selenium consumption). In this study which includes 31 samples in the control group and 31 in the test group, lymphocyte apoptosis was found to be associated with generation of free radicals and that the antioxidants significantly inhibit apoptotic process. It was noted that H2O2 enormously accelerates apoptosis.

Keywords: Apoptosis, antioxidants, trace metals, free radicals.

Fakher S. Al-Ani, Israa F. Al-Samaraee, Anam R. Abdul-Razzak. Antioxidants Prolong Survival of Lymphocytes. Med J Islamic World Acad Sci. 2000; 13(4): 141-145

Corresponding Author: Fakher S. Al-Ani, Iraq

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