Some Reactions of Pyrazolo (1,5-C) PyrimidinethionesMohammed G. MareiFrom Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia P.O. Box 426, Alexandria 21321, Egypt.
Bromination and iodination of the 2,5-diaryl-6H-pyrazolo [1,5-c] pyrimidine-7-thiones gave mono-and/or dihalogenation products, whereas nitration yielded only monosubstitution derivatives. However, with benzenediazonium chloride in the presence of sodium hydroxide afforded the respective monophenylazo disulfides. Acetylation, benzoylation and benzylation of 5-p-chlorophenyl-2-phenyl-6H-pyrazolo [1,5-c] pyrimidine-7-thione furnished the N-substituted derivatives. The pyrazolopyrimidinones were obtained by reaction with alkaline hydrogen peroxide. Keywords: Pyrazolo [1, 5-c] pyrimidines, bromination, iodination
Mohammed G. Marei. Some Reactions of Pyrazolo (1,5-C) Pyrimidinethiones. Med J Islamic World Acad Sci. 1993; 6(1): 8-14
Corresponding Author: Mohammed G. Marei, Egypt |
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