ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Some Reactions of Pyrazolo (1,5-C) Pyrimidinethiones [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1993; 6(1): 8-14

Some Reactions of Pyrazolo (1,5-C) Pyrimidinethiones

Mohammed G. Marei
From Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia P.O. Box 426, Alexandria 21321, Egypt.

Bromination and iodination of the 2,5-diaryl-6H-pyrazolo [1,5-c] pyrimidine-7-thiones gave mono-and/or dihalogenation products, whereas nitration yielded only monosubstitution derivatives. However, with benzenediazonium chloride in the presence of sodium hydroxide afforded the respective monophenylazo disulfides. Acetylation, benzoylation and benzylation of 5-p-chlorophenyl-2-phenyl-6H-pyrazolo [1,5-c] pyrimidine-7-thione furnished the N-substituted derivatives. The pyrazolopyrimidinones were obtained by reaction with alkaline hydrogen peroxide.

Keywords: Pyrazolo [1, 5-c] pyrimidines, bromination, iodination


Mohammed G. Marei. Some Reactions of Pyrazolo (1,5-C) Pyrimidinethiones. Med J Islamic World Acad Sci. 1993; 6(1): 8-14

Corresponding Author: Mohammed G. Marei, Egypt


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