Zinc Sulfate in Treatment of The Patients with Recurrent Aphtous Stomatitis

Twenty-six patients with recurrent aphtous stomatitis were studied with respect to zinc and copper deficiency. Their mean serum zinc levels before treatment was 78.23 ± 2.64 g/dl and after treatment 100.31 ± 3.56 g/dl (p < 0.05). Zinc content of 1010 erythrocytes was 11.35 ± 0.41 before and 13.54 ± 0.50 g after treatment (p<0.05) while serum copper levels were maintained almost at the same level (p>0.05). Of the total series, before treatment, serum Zn levels in 20 patients, serum copper levels in 5 patients, and Zn contents of 1010 erythrocytes in 18 patients were found below normal levels. Following one, two, and three months of treatment serum Zn levels and Zn contents of 1010 erythrocytes of patients rose parallel to the improvement in clinical findings. A significant remission was observed after the 3rd month of treatment in 22 (84.6%) of 26 patients. The differences between pre-treatment and of monthly evaluation following treatment in mean serum Zn levels and Zn contents of 1010 erythrocytes were statistically significant (p<0.05).