A Study of The Effect of Magnesium Hydroxide on The Wound Healing Process in Rats

Wound healing is the restoration of physical integrity to internal and external structures and involves intricate interactions between the cells and numerous other factors. Appropriate treatment and care are essential for acceleration of the healing process, prevention of infection and chronicity of the wound and different means and approaches have thus far been used to this end. The aim of this study was to evaluate the effect of magnesium hydroxide that was used for prevention of bed sores erstwhile on the wound healing process.
The effect of magnesium hydroxide on the healing process in two models of skin wound; length wounds of 15 mm full-thickness and round wounds of 5 mm in diameter full thickness incision were created in the paravertebral area, 1.5 mm from midline on the back of rats was evaluated through measuring the length and area of the healed region and process pathological on different days, and conducting tensiometry experiments after complete wound healing.
The percentage of wound healing on days 3, 6, 9, 12 and 15 in control group of length wounds changed in the group treated with magnesium hydroxide from 10.13%, 31.88%, 52.46%, 78.75% and 100% to 11.63%, 49.75% (p<0.05), 94% (p<0.01), 100% and 100% respectively; also the percentage of wound healing on days 3, 6, 9, 12, 15 and 18 in control group of round wounds changed in the group treated with magnesium hydroxide from 9.88%, 21.25%, 52.13%, 69.63%, 88.21% and 100% to 12.25%, 37.25% (p<0.05), 60.5%, 76%, 93.4% and 100% respectively.
Stress (maximum tensile force causing skin rupture) changed from 13.19 Newton (N) in the control group of length wound to 20.87 N, also from 11.78 N (p<0.05) in the control group of round wound to 16.9 N (p<0.05) in group treated with magnesium hydroxide.
Strain (tissue length under maximum strain) changed from 9.98 mm in the control group of length wound to 15.43 mm (p<0.05), also from 10.53 mm in the control group of round wound to 17 mm (p<0.05) in group treated with magnesium hydroxide.
The result of pathological samples of view histological (wound healing and cell aggregative) accelerated in magnesium groups on length and round wounds partition to control groups.
Our findings suggest that magnesium hydroxide may have accelerated the skin wound healing process in rat and increased tissue strength through stimulating collagen formation.