ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Effects of Palm Vitamin E, Vitamin D and Calcium Supplementation on Bone Metabolism in Vitamin E Deficient Rats [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1999; 12(4): 89-96

Effects of Palm Vitamin E, Vitamin D and Calcium Supplementation on Bone Metabolism in Vitamin E Deficient Rats

M. Norazlina1, S. Ima-Nirwana1, B.A.K. Khalid2
1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia.
2Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia.

The aim of this study was to determine the effects of vitamin E deficiency on bone metabolism in growing female rats. The effects of supplementation of these vitamin E deficient rats with palm vitamin E, calcium or vitamin D3, alone or in combination on bone growth and metabolism were also studied. The rats were fed with vitamin E deficient diet and divided into 6 groups: unsupplemented (control, VED), VED + palm vitamin E 60 mg/kg rat weight (PVE60), VED + 1% calcium in drinking water, ad libitum (Ca), VED + vitamin D3, 0.5 g/kg rat weight (D), VED + PVE60/Ca, VED + PVE60/D. Calcium supplementation increased bone mineral density and reduced bone resorption activity in vitamin E deficient rats. Supplementation with palm vitamin E 60 mg/kg body weight/day, which is a mixture of 30% -tocopherols and 70% tocotrienols, increased bone calcium content, but failed to increase bone mineral density. Vitamin D3, (cholecalciferol) 0.5 g/kg did not increase bone mineral density or bone calcium content in vitamin E deficient rats. Combination of palm vitamin E and calcium or palm vitamin E and vitamin D3, in the same doses did not offer any added advantage to using each supplement alone. In conclusion, both calcium and vitamin E were needed for normal bone growth and development. Supplementation of vitamin D3, in a state of vitamin E deficiency was ineffective. However, the mechanism by which vitamin E deficiency impaired bone metabolism required further study.

Keywords: Bone metabolism, calcium, vitamin D3, vitamin E deficiency.


M. Norazlina, S. Ima-Nirwana, B.A.K. Khalid. Effects of Palm Vitamin E, Vitamin D and Calcium Supplementation on Bone Metabolism in Vitamin E Deficient Rats. Med J Islamic World Acad Sci. 1999; 12(4): 89-96

Corresponding Author: S. Ima-Nirwana, Malaysia


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