Visualization of Bone Tumors with 99mTc-GP: A Comparative Study

The potential of 99mTc-GP as a lung tumor scanning agent was reported. In this study, we adressed the question of whether 99mTc-GP can accumulate in various bone disease. 22 patients with various bone disease were studied by 99mTc-GP as well as by 99mTc-MDP. We report the results of the visualization and quantitation of 99mTc-GP uptake and a comparison with 99mTc-MDP. All bone pathologies demonstrated by 99mTc-MDP were also visualized with 99mTc-GP. Althoungh the target/nontarget ratios obtained by 99mTc-GP were inferior to those obtained by 99mTc-MDP, the differences were not significant for all kinds of bone pathologies (p>0.05). It was concluded that although 99mTc-GP can demostrate the bone pathologies; it is not as sensitive and specific as 99mTcMDP. The mechanism of 99mTc-GP uptake in bone pathologies is not clearly understood.