Role of intraperitoneal propolis treatment in preventing postoperative peritoneal adhesionsBirkan Birben1, Gökhan Akkurt1, Tugan Tezcaner2, Eda Özturan Özer2, Firdevs Zeynep Taştepe3, Feza Karakayalı4, Gökhan Moray21Ankara City HospitalAnkara City Hospital, Department of General Surgery, Ankara, Turkey 2Ankara Baskent University Hospital, Department of Biochemistry, Ankara, Turkey 3Ankara Forensic Institution, Department of Pathology, Ankara, Turkey 4Istanbul Baskent University Hospital, Department of General Surgery, Istanbul, Turkey
This study aimed to evaluate the anti-inflammatory and anti-oxidant properties of propolis and its effect on the fibrinolytic system in postoperative adhesions. The rats were randomly divided into 3 groups of 10, and a modified cecal abrasion model was created. Group 1 was the sham group. Group 2 received 0.4 mL of ethanol (96%), while Group 3 was administered 0.4 mL of propolis (900 mg/kg) and ethanol (96%) solution intraperitoneally. The adhesions were evaluated macroscopically and microscopically. The adhesion in the propolis group was significantly higher according to the scores of Nair (ethanol–propolis P > 0.002 and sham–propolis, P > 0.023) and Zühlke (ethanol–propolis P > 0.033 and sham–propolis P > 0.024). Propolis administration was significantly associated with increased fibrosis (P > 0.01) and vascular proliferation (P > 0.01). The increase in peritoneal adhesion in the propolis group might have been due to propolis being retained in the abdomen longer than normal and the higher concentration of the solvent. Keywords: Anti-inflammatory, anti-oxidant, peritoneal adhesion, propolis
Birkan Birben, Gökhan Akkurt, Tugan Tezcaner, Eda Özturan Özer, Firdevs Zeynep Taştepe, Feza Karakayalı, Gökhan Moray. Role of intraperitoneal propolis treatment in preventing postoperative peritoneal adhesions. Med J Islamic World Acad Sci. 2020; 28(1): 12-17
Corresponding Author: Gökhan Akkurt, Türkiye |
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