Net Insulin Secretion and Irý Response Per Unit of Glucose during Hypotension and Shock

In anesthetized dogs after necessary preparations pancreatic blood flow, insulin, concentrations in pancreatic venous and arterial plasma were determined. Net insulin secretion (the difference between inflowing and outflowing insulin per 100 gram of pancreas per minute), the amount of inflowing glucose into the pancreas (mg/100g P/min) and the insulin response to 1 mg of glucose (insulin secretion index) were calculated under control conditions and during hypotention and shock.
Arterial plasma insulin concentration showed a marked increase in hypotension (p<0.01) and shock (p<0.001) as did pancreatic venous plasma insulin concentration (p<0.01). Inflow of glucose to pancreas however was very significantly decreased (p<0.001) reflecting the reduced blood flow. Net insulin secretion of pancreas was also reduced significantly during shock (p<0.05), while insulin secreted in response to 1 mg of glucose insulin secretion index revealed a statistically to 1 mg of glucose insulin secretion index revealed a statistically important increase (p<0.01). Linear correlation was observed between some of these parameters while others revealed non-linear (logarithmic, exponential or hyperbolic) relationships.