Alveolar soft-part sarcoma: Analysis of 312 cases

Alveolar soft-part sarcoma (ASPS) is a rare soft tissue malignant tumor. This study aimed to evaluate the epidemiological data of ASPS. Data on ASPS were obtained from Surveillance, Epidemiology, and End Results (SEER) database. Patients diagnosed with ASPS between 1975 and 2016 were scanned retrospectively. Age, sex, ethnicity, disease prognosis, tumor location, tumor grade, follow-up time, and follow-up results of all patients were evaluated. A total of 312 patients with ASPS [171 female (54.8%), mean age 27.4 (1–84 years)] were included. The most common tumor location was soft tissues (84.2%). The mean follow-up duration was 86.8 months (range 1–484 months). The most common tumor grade was grade 4, with 30 patients in this category (43.4%). At the time of diagnosis, 104 (48.5%) patients had distant metastasis. ASPS is a rare soft tissue sarcoma, and approximately half of the patients are metastatic at the time of diagnosis with metastasis to the lungs, most commonly. Despite the high metastasis rate, ASPS has a satisfactory 5-year survival rate