Effect of Hypothermia on Rat Brain ATPase Activity

The study deals with the activity of Na, K-ATPase and Mg-ATPase in rat sub cellular fractions and cerebral cortex homogenates and its response to 20°C hypothermia during 1 and 3 hours with the intra-abdominal injection of neuropeptide dalargin. The results show that the prolonged hypothermia for 1 and 3 hours intensifies the activity of Na, K-ATPase in all examined fractions with the only exception Mg-ATPase in mitochondrial fraction where 3 hours hypothermia brings the activity down. Intra-abdominal injection of dalargin (200g/kg) considerably abates the activity of Na, KATPase during 1 hour hypothermia. Under the discussion are the possible causes that advance the activity of Na, K-ATPase with the influence of hypothermia.