ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
Angiotensin II Receptor Blocker Valsartan Enhances Glucose-Induced Insulin Secretion [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2006; 16(1): 11-17

Angiotensin II Receptor Blocker Valsartan Enhances Glucose-Induced Insulin Secretion

Azizi Ayob1, Suhaimi Hashim2, Zulnizam Azdan2, Tariq A. Razak3
1Pharmacology Unit, Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), 25200 Kuantan, Malaysia.
2Pharmacology Diagnostic Laboratory, Kulliyyah of Medicine, IIUM, Malaysia.
3Kulliyyah of Pharmacy, IIUM, Kuantan 25200, Pahang, Malaysia.

A number of antihypertensive drugs are known to be diabetogenic. This may contribute to less than expected decrease in the incidence of coronary heart disease with reduction in blood pressure with treatment in hypertensive patients. This study was aimed to determine the effects of a member, Valsartan, of a new class of drugs, angiotensin II receptor blocker, on glucose induced insulin secretion. Male albino rat pancreases were used. The isolated pancreases were perfused with Kreb's solution containing bovine albumin (200 mg/dl) with low glucose (60 mg/dl) followed by high glucose (300 mg/dl) at a rate of 4 ml/min. The dose of Valsartan used was based on the peak plasma level achieved in human at standard single oral dose of 80 mg daily, which was 1.64 mg/L. Five treatment groups were used: Control group, Valsartan at 10%, Valsartan at 100% and Valsartan at 10 times of the 1.64 mg/L, and Diazoxide 10 g/ml group. Insulin levels in the perfusate were measured by radioimmunoassay. Valsartan at all concentrations significantly increases glucose induced insulin secretion (p < 0.05). Valsartan at 10 %, Valsartan at 100% and Valsartan at 10 times of the 16.4 mg/L, increases glucose induced insulin secretion by 226.4 %, 161.7 % and 156.3 %, respectively. Diazoxide, significantly inhibits glucose induced insulin secretion (p < 0.05).
Valsartan at all concentrations enhances glucose-induced insulin secretion in isolated rat pancreas technique.

Keywords: Angiotensin II, Valsartan, Pancreas, Hypertension, Insulin.


Azizi Ayob, Suhaimi Hashim, Zulnizam Azdan, Tariq A. Razak. Angiotensin II Receptor Blocker Valsartan Enhances Glucose-Induced Insulin Secretion. Med J Islamic World Acad Sci. 2006; 16(1): 11-17

Corresponding Author: Azizi Ayob, Malaysia


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




   
Copyright 2020 medicaljournal-ias.org. All Rights Reserved.