ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
Volume : 30 Issue : 1 Year : 2023
Can different fatty acid contents in propofol formulations change bacterial growth? [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 2018; 26(4): 108-113 | DOI: 10.5505/ias.2018.98704  

Can different fatty acid contents in propofol formulations change bacterial growth?

İbrahim Halil Ertaş1, İbrahim Andan2, Mihriban Yücel3, Türkay Çakan4, Hülya Teltik Başar4
1Department of Anesthesiology and Reanimation, Ersin Arslan Training and Research Hospital, Gaziantep, Turkey
2Department of Anesthesiology and Reanimation, Ahi Evran University Training and Research Hospital, Kırşehir, Turkey
3Department of Microbiology, Ankara Training and Research Hospital, Ankara, Turkey
4Department of Anesthesiology and Reanimation, Ankara Training and Research Hospital, Ankara, Turkey

This study aimed to investigate how Propofol-Lipuro changed the quantity of bacterial growth compared with propofol after changing the lipid content of Propofol-Lipuro. Seven microorganisms (methicillin-resistant Staphylococcus aureus, methicillin-sensitive Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Serratia marcescens), representing different groups that cause hospital-acquired infections and have been already investigated in previous studies, were selected. Each microorganism used in the study was incubated in 5% sheep blood agar at 36°C, and reproduction was enabled after 24 h. Three different groups were generated from each microorganism by inoculating the microorganism suspension with10-mL physiological serum (PS), propofol (P), and Propofol-Lipuro (PL). The quantitative growth levels were evaluated by repeated procedures at 36°C after 4, 8, 24, and 48 h. Although a statistically significant difference in terms of quantity of bacterial growth was detected in both propofol formulations (group P and group PL) compared with the control group (PS), no statistically significant difference was detected between the P and PL groups. No difference was detected in terms of bacterial growth in different lipid contents. In conclusion, this study suggested the use of aseptic methods and administration in accordance with the updated recommendations in the literature while using propofol formulations.

Keywords: Bacterial growth, contamination, fatty acids, Propofol-Lipuro

İbrahim Halil Ertaş, İbrahim Andan, Mihriban Yücel, Türkay Çakan, Hülya Teltik Başar. Can different fatty acid contents in propofol formulations change bacterial growth?. Med J Islamic World Acad Sci. 2018; 26(4): 108-113

Corresponding Author: İbrahim Andan, Türkiye

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