ISSN 2415-1297 (Online)   ISSN 2415-1300 (Print)
 
             
 
Volume : 27 Issue : 3 Year : 2019
 
111In or 125I Labeled Epidermal Growth Factor for The In Vivo Localization of EGF Receptors: In Vivo Stability [Med J Islamic World Acad Sci]
Med J Islamic World Acad Sci. 1991; 4(2): 123-126

111In or 125I Labeled Epidermal Growth Factor for The In Vivo Localization of EGF Receptors: In Vivo Stability

Meral T. Ercan1, Reingard Senekowitsch2
1From Hacettepe Universitesi Tip Fakültesi, Nükleer Tip Anabilim Dali, Ankara, Türkiye.
2From Institut für Strahlenbiologie, Gesellschaft für Strahlen-und Umweltforschung, mbH München, Ingolstadier Landsrabe 1, D- 8042 Neuherberg, Germany.

Radio iodinated epidermal growth factor (125I-EGF) used for the detection EGF receptors in implanted tumors in mice showed rapid in vivo de-iodination. To increase its stability EGF was labeled with 111In and its biodistribution in normal NMRI mice was determined and compared to 125I-EGF. The highest accumulation was observed in the thyroid (max at 6 h: 1045.2 ± 376.4 % /g) with 125I-EGF. 111In-EGF demonstrated prolonged blood clearance and whole body retention compared to 125I-EGF. High renal activity (23.79 ± 3.41% /g) indicated excretion via kidneys. 111In labeling increased the stability of the radiotracer. Further studies in tumor implanted nude mice are warranted to demonstrate the biological efficacy of 111In labeling.

Keywords: 111In-EGF, 125I-EGF, EGF receptors, ITLC.


Meral T. Ercan, Reingard Senekowitsch. 111In or 125I Labeled Epidermal Growth Factor for The In Vivo Localization of EGF Receptors: In Vivo Stability. Med J Islamic World Acad Sci. 1991; 4(2): 123-126

Corresponding Author: Meral T. Ercan, Türkiye


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