Idiopathic Thrombocytopenic Purpura in Childhood. Review 269 Cases.

Our experience with idiopathic thrombocytopenic purpura (ITP) on 269 cases is reviewed and the general lines are resented in this communication.
Presence of antiplatelet antibody both in thrombocytopenic phase and remission was shown in all acute and chronic ITP patients. Abreviation of ITP was therefore proposed to signify immune thrombocytopenic purpura. Because of shorter platelet survival observed in 8 acute 6 chronic ITP cases in remission increased platelet production was considered. As an etiologic factor rubella infection was scrutinized in one epidemic. Low serum IgA levels were documented in one third of acute and chronic ITP cases.
High dose I.V. methyl prednisolane was proposed for the first time and its superiority demonstrated over conventional prednisone administration in ITP.
As a conclusion it appears that high dose of intravenous methyl prednisolon in presently the choise of treatment for ITP.